Shi, Shiliang   Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone/Fax: +86 21 54925580


Education and Research Experience:

2016.06-Present: Professor, State Key Laboratory of Organometallic Chemistry, SIOC

2012.11-2016.05: Postdoctoral Associate, Department of Chemistry, Massachusetts Institute of Technology (Advisor: Prof. Stephen L. Buchwald)

2011.10-2012.10 JSPS Postdoctoral Fellow, Graduate School of Pharmaceutical Sciences, University of Tokyo, (Advisor: Prof. Motomu Kanai)

2008.10-2011.09 Ph.D., Graduate School of Pharmaceutical Sciences, University of Tokyo, (Advisor: Prof. Masakatsu Shibasaki and Motomu Kanai)


Awards & Honors:

Chinese Government Award for Outstanding Self-Financed Students Abroad, 2010

Japan Society for the Promotion of Science (JSPS) Fellowships (DC2 and PD)

Japanese Government (Monbukagakusho: MEXT) Scholarship

2019 Thieme Chemistry Journals Award

Research Interest:

· Development of New Privileged Chiral Ligands

· Development of Novel, Efficient, and Practical Enantioselective Catalytic Reactions

· Design and Syntheses of New Optically Active Polymers

Selected Publications

1. Wu-Bin Zhang#, Xin-Tuo Yang#, Jun-Bao Ma, Zhi-Min Su, Shi-Liang Shi* Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis. J. Am. Chem. Soc. 2019, 141, 5628.

2. Di Shen, Youjun Xu, Shi-Liang Shi* A Bulky Chiral N-Heterocyclic Carbene Palladium Catalyst Enables Highly Enantioselective Suzuki-Miyaura Cross-Coupling Reactions for the Synthesis of Biaryl Atropisomers. J. Am. Chem. Soc. 2019, 141, 14938.

3. Yuan Cai, Xiaodong Ye, Sheng Liu, Shi-Liang Shi* Nickel/NHC-Catalyzed Asymmetric C–H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins. Angew. Chem. Int. Ed. 2019, 58, 13433.

4. Yuan Cai, Jia-Wen Zhang, Feng Li, Jia-Ming Liu, Shi-Liang Shi* Nickel/N-Heterocyclic Carbene Complex-Catalyzed Enantioselective Redox-Neutral Coupling of Benzyl Alcohols and Alkynes to Allylic Alcohols. ACS Catal. 2019, 9, 1.

5. Zi-Chao Wang, Di Shen, Jian Gao, Xian Jia, Youjun Xu*, Shi-Liang Shi* Base-Catalysed Reductive Relay Hydroboration of Allylic Alcohols with Pinacolborane to Form Alkylboronic Esters. Chem. Common., 2019, 55, 8848. (Invited Contribution to the ChemComm Emerging Investigators Issue 2019).

6. Di Shen, Wu-Bin Zhang, Zhiyang Li, Shi-Liang Shi*, Youjun Xu* Nickel/NHC-Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes. Adv. Synth. Catal. 2020, 362, 1125.

7. Yuan Cai, Xin-Tuo Yang, Shuo-Qin Zhang, Feng Li, Yu-Qin Li, Lin-Xin Ruan, Xin Hong*, Shi-Liang Shi* Copper-Catalyzed Enantioselective Markovnikov Protoboration of a-Olefins Enabled by a Buttressed N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed. 2018, 57, 1376.

8. Shi-Liang Shi, Zackary L. Wong, Stephen L. Buchwald* Copper-Catalyzed Enantioselective Stereodivergent Synthesis of Amino Alcohols. Nature 2016, 532, 353.

9. Shi-Liang Shi, Stephen L. Buchwald* Copper-catalysed Selective Hydroamination Reactions of Alkynes. Nature Chemistry 2015, 7, 38. (Highlighted in Nature. Nature 517, 280.)

10. Yang Yang#, Shi-Liang Shi#, Dawen Niu, Peng Liu, Stephen L. Buchwald* Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines. Science 2015, 349, 62. (#: Co-first author) (Highlighted in Chemistry World and C&EN)