You, Shuli  Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone: +86 21 54925085

Fax: +86 21 54925087



09/1996 - 07/2001  Ph.D. (Advisor: Prof Lixin Dai), Shanghai Institute of Organic Chemistry

09/1992 - 07/1996  B.S. (Chemistry), Nankai University.

Research Experience:

04/2006 - present   Professor, State Key Laboratory of OrganometallicChemistry, SIOC

02/2004 - 04/2006  Principal Investigator, Genomics Institute of the Novartis Research Foundation

09/2001 - 01/2004  Postdoctoral fellow, The Scripps Research Institute (Advisor: Prof. Jeffery W. Kelly)

Awards & Honors:

Advisory Board, Chemical Society Reviews, 2011.1.1-

Advisory Board, Organic & Biomolecular Chemistry, 2011.1.1-

AstraZeneca Excellence in Chemistry Award (2011)

The National Science Fund for Distinguished Young Scholars (2010)

Thieme Chemistry Journals Award (2010)

The Chinese Chemical Society Young Chemist Award (2008)

CAPA Distinguished Faculty Award from Chinese-American Chemistry & Chemical Biology Professors Association (2008)

The CCS-Wiley Young Chemist Award (2007)

The Top 100 Best Ph. D. Theses in 2003

The Excellent Achievement Award of Shanghai Graduate Students (Theses) in 2003

The Special Prize of the President Scholarship for Postgraduate Student in 2001

Research Interest:

Transition-metal catalyzed reactions;

Asymmetric catalysis based on the C-H direct functionalization and dearomatization;

Green chemistry-oriented novel methodology

Selected Publications:

1. Wu, Q.-F.; Zheng C.; You, S.-L.* Enantioselective Syntheses of Spiro Cyclopentane-1,3'-indoles and 2,3,4,9-Tetrahydro-1H-carbazoles via Ir-Catalyzed Allylic Dearomatization and Stereospecific Migration. Angew. Chem. Int. Ed. 2012, 51, in press.

2. Liu, W.-B.; Xia, J.-B.; You, S.-L.* Iridium-Catalyzed Asymmetric Allylic Substitutions Top. Organomet. Chem. 2012, 38, 155-208.

3. Zheng, C.; You, S.-L.* Transfer Hydrogenation with Hantzsch Esters and Related Organic Hydride Donors Chem. Soc. Rev. 2012, 41, in press. (invited review)

4. Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L.* Asymmetric Dearomatization of Pyrroles via Ir-Catalyzed Allylic Substitution Reaction: Enantioselective Synthesis of Spiro-2H-pyrroles.Chem. Sci. 2012, 3, 205-208.

5. Ye, K.-Y.; He, H.; Liu, W.-B.; Helmchen, G.; Dai, L-X.; You, S.-L.* Iridium-Catalyzed Allylic Vinylation and Asymmetric Allylic Amination Reactions with ortho-Aminostyrenes J. Am. Chem. Soc. 2011, 133, 19006-19014.

6. Cai, Q.; Zheng, C.; Zhang, J.-W.; You, S.-L.* Enantioselective Michael-Mannich Polycyclization Cascade of Indolyl Enones by Quinine-Derived Primary Amine Angew. Chem. Int. Ed. 2011, 50, 8665-8669.

7. Gu, Q.; You, S.-L.* Desymmetrization of Cyclohexadienones via Cinchonine Derived Thiourea-Catalyzed Enantioselective Aza-Michael Reaction and Total Synthesis of (-)-Mesembrine.Chem. Sci. 2011, 2, 1519-1522.

8. Yin, Q.; You, S.-L.* Chiral Phosphoric Acid-Catalysed Friedel-Crafts Alkylation Reaction of Indoles with Racemic Spiro Indolin-3-ones. Chem. Sci. 2011, 2, 1344-1348.

9. Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Ir-Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.

10. You, S.-L.*, Xia, J.-B. Palladium-Catalyzed Aryl–Aryl Bond Formation Through Double C–H Activation Top. Curr. Chem., 2010, 292, 165-194. (invited review)

11. Cai, Q.; Zheng, C.; You, S.-L.* Chiral Phosphoric Acid-Catalyzed Enantioselective Intramolecular Aza-Michael Addition of Indoles Angew. Chem. Int. Ed. 2010, 49, 8666-8669.

12. Wu, Q.-F.; He, H.; Liu, W.-B.; You, S.-L.* Enantioselective Construction of Spiroindolenines by Ir-Catalyzed Allylic Alkylation Reactions J. Am. Chem. Soc. 2010, 132, 11418-11419.

13. Peng, H. M.; Dai, L.-X.; You, S.-L.* Enantioselective Palladium-Catalyzed Direct Alkylation and Olefination Reaction of Simple Arenes Angew. Chem. Int. Ed. 2010, 49, 5826-5828. (Highlights)

14. He, H.; Liu, W.-B.; Dai, L.-X.; You, S.-L.* Enantioselective Synthesis of 2,3-Dihydro-1H-benzo[b]azepines via Ir-Catalyzed Tandem Allylic Vinylation/Amination Reaction. Angew. Chem. Int. Ed. 2010, 49, 1496-1499.

15. Gu, Q.; Rong, Z.-Q.; Zheng, C.; You, S.-L.* Desymmetrization of Cyclohexadienones via Brønsted Acid-Catalyzed Enantioselective Oxo-Michael Reaction J. Am. Chem. Soc. 2010, 132, 4056-4057.

16. Cai, Q.; Zhao, Z.-A.; You, S.-L.* Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis. Angew. Chem. Int. Ed. 2009, 48, 7428-7431.

17. He, H.; Liu, W.-B.; Dai, L.-X.; You, S.-L.* Ir-Catalyzed Cross-Coupling of Styrene Derivatives with Allylic Carbonates: Free Amine Assisted Vinyl C-H Bond Activation J. Am. Chem. Soc. 2009, 131, 8346-8347.

18. You, S.-L.*; Cai, Q.; Zeng, M. Chiral Brønsted Acids Catalyzed Friedel-Crafts Alkylation Reaction Chem. Soc. Rev. 2009, 38, 2190-2201. (invited review)

19. Kang, Q.; Zhao, Z.-A.; You, S.-L.* Highly Enantioselective Friedel-Crafts Reaction of Indoles with Imines by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2007, 129, 1484-1485.

20. Xia, J.-B.; You, S.-L.* Carbon-Carbon Bond Formation through Double sp2 C-H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives. Organometallics 2007, 26, 4869-4871.

21. You, S.-L.*; Dai, L.-X. Enantioselective Palladium-Catalyzed Decarboxylative Allylic Alkylations. Angew. Chem. Int. Ed. 2006, 45, 5246-5248. (Highlights)