Liu, Yuanhong   Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone: +86 21 54925135

Fax: +86 21 64166128

Email: yhliu@sioc.ac.cn

Education:

09/1988 - 07/1992  Zhengzhou University, B. Sc

09/1992 - 07/1995  Department of Chemistry, Zhengzhou University, M. Sc.

04/1997 - 03/2000  Hokkaido University, Ph. D. Advisor: Professor Tamotsu Takahashi

Academic Career:

04/2000 - 12/2000  Postdoctoral Fellow with JSPS fellowship, Hokkaido University

01/2001 - 12/2002  COE research fellow, Hokkaido University. Advisor: Professor Tamotsu Takahashi

01/2003 - 09/2003  PostdoctoralFellow, Hokkaido University

10/2003 - present Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Awards & Honors:

Awarded by the Hundred Talent Program of the Chinese Academy of Sciences (2004)

Thieme Chemistry Journals Award (2007)

The Distinguished Lectureship Award from the Chemical Society of Japan (2007)

Research Interests:

new synthetic methodologies mediated by metallacycles;

activation of alkenes, alkynes and polyynes by early transition metals;

construction of carbocyclic or heterocyclic molecules;

organic synthesis catalyzed by homogeneous organometallic complexes;

synthesis of new π-conjugated functional materials

Selective Publications:

1. Gold-Catalyzed Cyclizations of (o-Alkynyl)phenoxyacrylates with External Nucleophiles: Regio- and Stereoselective Synthesis of Functionalized Benzo[b]oxepines. Jun Liu, Yuanhong Liu* Org. Lett. 2012, in press.

2. Unexpected Multi-Component Reactions of Conjugated 1,3-Butadiynes or Monoynes with Acyl Cyanide Derivatives Mediated by Zirconium. Shasha Yu, Xu You, Yuanhong Liu* Chem. Eur. J. 2012, in press.

3. Gold-Catalyzed Cyclization of 1,6-Diyne-4-en-3-ols: Stannyl Transfer from 2-Tributylstannylfuran Through Au/Sn Transmetalation, Yifeng Chen, Ming Chen, and Yuanhong Liu*. Angew. Chem. Int. Ed. 2012, 51, 6181.

4. Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Arylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification. Yifeng Chen, Ming Chen, and Yuanhong Liu*Angew. Chem. Int. Ed. 2012, 51, 6493.

5. Nucleophilic Addition of Grignard Reagents to 3-Acylindoles: Stereoselective Synthesis of Highly Substituted Indoline Scaffolds. Lu Wang, Yushang Shao, and Yuanhong Liu*, Org. Lett. 2012, 14, 3978.

6. Highly Efficient Synthesis of cis-[3]Cumulenic Diols via Zirconocene-Mediated Coupling of 1,3-Butadiynes with Aldehydes, Xiaoping Fu, Shasha Yu, Guoqin Fan, Yuanhong Liu* and Yuxue Li, Organometallics 2012, 31, 531.

7. Gold-Catalyzed Furan/Yne Cyclizations for the Regiodefined Assembly of Multisubstituted Protected 1-Naphthols, Chengyu Wang, Yifeng Chen, Xin Xie, Jun Liu and Yuanhong Liu*, J. Org. Chem. 2012, 77, 1915−1921.

8. Titanium-Mediated Cross-Coupling Reactions of Imines with Ketones or Aldehydes: An Efficient Route for the Synthesis of 1,2-Amino Alcohols, Guoqin Fan and Yuanhong Liu, Tetrahedron Lett. 2012, 53, 5084. 

9. One-Pot Synthesis of Indole-Fused Scaffolds via Gold-Catalyzed Tandem Annulation Reactions of 1,2-Bis(alkynyl)-2-en-1-ones with Indoles, Xin Xie, Xiangwei Du, Yifeng Chen, and Yuanhong Liu*, J. Org. Chem. 2011, 76, 9175–9181.

10. Gold-Catalyzed Deacylative Cycloisomerization Reactions of 3-Acylindole/ynes: A New Approach for Carbazole Synthesis,Lu Wang, Guijie Li, and Yuanhong Liu*, Org. Lett. 2011, 13, 3786-3789.

11. Grignard Reagent Acceleration of the Intramolecular Diels-Alder Reaction of Furans with Unactivated Alkynes: Toward Structurally Complex Oxabicyclic Alkenes. Yifeng Chen, Lu Wang, Yuanhong Liu* and Yuxue Li*, Chem. Eur. J. 2011, 17, 12582.

12. Regio- and Stereoselective Construction of Highly Functionalized 3-Benzazepine Skeletons through Ring-Opening Cycloamination Reactions Catalyzed by Gold. Xiangwei Du, Shuang, Yang, Jingyu Yang and Yuanhong Liu*, Chem. Eur. J. 2011, 17, 4981-4985.

13. Gold-Catalyzed Approach to Multisubstituted Fulvenes via Cycloisomerization of Furan/Ynes, Yifeng Chen and Yuanhong Liu*, J. Org. Chem. 2011, 76, 5274.

14. Gold-Catalyzed Cascade Friedel-Crafts/Furan-Yne Cyclization/Heteroenyne Metathesis for the Highly Efficient Construction of Phenanthrene Derivatives. Yifeng Chen, Guijie Li and Yuanhong Liu*, Adv. Synth. Catal. 2011, 353, 392– 400.

15. Highly Efficient Synthesis of Multisubstituted 2-Acyl Furans via PIFA/I2 Mediated Oxidative Cycloisomerization of cis-2-En-4-yn-1-ols. Xiangwei Du, Haoyi Chen, Yifeng Chen, Jingjin Chen and Yuanhong Liu*, Synlett 2011, 1010.

16. Gold and Brønsted Acid Catalyzed Isomerization of [3]Cumulenols and [3]Cumulenones: Efficient Syntheses of 1,5-Dien-3-ynes and Furan Derivatives. Erjuan Wang, Xiaoping Fu, Xin Xie, Jingjin Chen, Hongjun Gao and Yuanhong Liu*, Tetrahedron Lett. 2011, 52, 1968.

17. Highly Stereoselective Synthesis of Trisubstituted cis-[3]Cumulenols from Alkynylated Oxatitanacycles in the Presence of Lewis acids, Chen, J.; Liu,* Y. Organometallics 2010, 29, 505.

18. Gold-Catalyzed Cyclization of Alkynylaziridines as An Efficient Approach Toward Functionalized N-Phth Pyrroles. Xiangwei Du, Xin Xie and Yuanhong Liu*, J Org. Chem. 2010, 75, 510-513.

19. Gold-Catalyzed Benzannulation of 3-Alkoxy-1,5-enynes: Access to Functionalized Benzenes. Guijie Li and Yuanhong Liu*, J. Org. Chem. 2010, 75, 2903–2909.

20. Stereoselective synthesis of enynones via base-catalyzed isomerization of 1,5-disubstituted-2,4-pentadiynyl silyl ethers or their alcohol derivatives.Jingjin Chen, Guoqin Fan and Yuanhong Liu*, Org. Biomol. Chem. 2010, 8, 4806–4810.

21. 过渡金属催化的呋喃合成。卢玉华,宋飞杰,贾学顺*,刘元红*化学进展2010, 22, 58-70.

22. Gold-catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation, Li, G.; Liu,*Y. J. Org. Chem. 2010, 75, 3526.

23. Aldehyde Addition to 1,3-Butadiyne-Derived Zirconacyclocumulenes: Stereoselective Synthesis of cis-[3]Cumulenols, Fu, X.; Liu,* Y.;  Li*, Y. Organometallics 2010, 29, 3012.

24. Diverse Reactivity of Zirconacyclocumulenes Derived from Coupling of Benzynezirconocenes with 1,3-Butadiynes towards Acyl Cyanides: Synthesis of Indeno[2,1-b]pyrroles or [3]Cumulenones. Fu, X.; Chen, J.; Li, G.; Liu,* Y. Angew. Chem. Int. Ed. 2009, 48, 5500.

25. Gold-Catalyzed Cascade Friedel-Crafts/Furan-Alkyne Cycloisomerizations for the Highly Efficient Synthesis of Arylated (Z)-Enones or –Enals. Chen, Y.; Lu, Y.; Li, G.; Liu,* Y. Org. Lett. 2009, 11, 3838.

26. Stereoselective Synthesis of β-Hydroxyallenes with Multiple Contiguous tereogenic Centers via Aldehyde Addition to a-alkenyl-Substituted irconacyclopentenes. Zhou, Y.; Chen, J.; Zhao, C.; Wang, E.; Liu,* Y.; Li,*Y. J. Org. Chem. 2009, 74, 5326.

27. Gold-Catalyzed Intermolecular Reactions of (Z)-Enynols with Indoles for the Construction of Dihydrocyclohepta[b]indole Skeletons through a Cascade Friedel–Crafts/Hydroarylation Sequence. Lu, Y.; Du, X.; Jia, X.; Liu,* Y. Adv. Synth. Catal. 2009, 351, 1517.

28. New Synthetic Approach for the Construction of Multi-Substituted 2-Acyl Furans via IBX-Mediated Cascade Oxidation/Cyclization of cis-2-En-4-yn-1-ols. Du, X.; Chen, H. ; Liu,* Y. Chem. Eur. J. 2008, 14, 9495.

29. Gold-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines and Alkynes Under Solvent-Free Conditions or in Water. Yan, B.; Liu,* Y. Org. Lett. 2007, 9, 4323.

30. General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions. Liu,* Y.; Song, Z.; Yan, B. Org. Lett. 2007, 9, 409.

31. Highly Stereoselective Synthesis of TMS-, Alkyl-, or Aryl Substituted cis-[3]cumulenols via a-alkynylated zirconacyclopentenes. Liu,* Y.; Gao, H.; Zhou, S. Angew. Chem. Int. Ed. 2006, 45, 4163.