Liu, Yuanhong   Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone: +86 21 54925135

Fax: +86 21 64166128



09/1988 - 07/1992  Zhengzhou University, B. Sc

09/1992 - 07/1995  Department of Chemistry, Zhengzhou University, M. Sc.

04/1997 - 03/2000  Hokkaido University, Ph. D. Advisor: Professor Tamotsu Takahashi

Academic Career:

04/2000 - 12/2000  Postdoctoral Fellow with JSPS fellowship, Hokkaido University

01/2001 - 12/2002  COE research fellow, Hokkaido University. Advisor: Professor Tamotsu Takahashi

01/2003 - 09/2003  PostdoctoralFellow, Hokkaido University

10/2003 - present Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Awards & Honors:

Thieme Chemistry Journals Award (2007)

The Distinguished Lectureship Award from the Chemical Society of Japan (2007)

Research Interests:

new synthetic methodologies mediated by metallacycles;

activation of alkenes, alkynes and polyynes by early transition metals;

construction of carbocyclic or heterocyclic molecules;

organic synthesis catalyzed by homogeneous organometallic complexes;

synthesis of new π-conjugated functional materials

Selective Publications:

1. Gold-Catalyzed Cyclizations of (o-Alkynyl)phenoxyacrylates with External Nucleophiles: Regio- and Stereoselective Synthesis of Functionalized Benzo[b]oxepines. Jun Liu, Yuanhong Liu* Org. Lett. 2012, in press.

2. Unexpected Multi-Component Reactions of Conjugated 1,3-Butadiynes or Monoynes with Acyl Cyanide Derivatives Mediated by Zirconium. Shasha Yu, Xu You, Yuanhong Liu* Chem. Eur. J. 2012, in press.

3. Gold-Catalyzed Cyclization of 1,6-Diyne-4-en-3-ols: Stannyl Transfer from 2-Tributylstannylfuran Through Au/Sn Transmetalation, Yifeng Chen, Ming Chen, and Yuanhong Liu*. Angew. Chem. Int. Ed. 2012, 51, 6181.

4. Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Arylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification. Yifeng Chen, Ming Chen, and Yuanhong Liu*Angew. Chem. Int. Ed. 2012, 51, 6493.

5. Nucleophilic Addition of Grignard Reagents to 3-Acylindoles: Stereoselective Synthesis of Highly Substituted Indoline Scaffolds. Lu Wang, Yushang Shao, and Yuanhong Liu*, Org. Lett. 2012, 14, 3978.

6. Highly Efficient Synthesis of cis-[3]Cumulenic Diols via Zirconocene-Mediated Coupling of 1,3-Butadiynes with Aldehydes, Xiaoping Fu, Shasha Yu, Guoqin Fan, Yuanhong Liu* and Yuxue Li, Organometallics 2012, 31, 531.

7. Gold-Catalyzed Furan/Yne Cyclizations for the Regiodefined Assembly of Multisubstituted Protected 1-Naphthols, Chengyu Wang, Yifeng Chen, Xin Xie, Jun Liu and Yuanhong Liu*, J. Org. Chem. 2012, 77, 1915?1921.

8. Titanium-Mediated Cross-Coupling Reactions of Imines with Ketones or Aldehydes: An Efficient Route for the Synthesis of 1,2-Amino Alcohols, Guoqin Fan and Yuanhong Liu, Tetrahedron Lett. 2012, 53, 5084. 

9. One-Pot Synthesis of Indole-Fused Scaffolds via Gold-Catalyzed Tandem Annulation Reactions of 1,2-Bis(alkynyl)-2-en-1-ones with Indoles, Xin Xie, Xiangwei Du, Yifeng Chen, and Yuanhong Liu*, J. Org. Chem. 2011, 76, 9175–9181.

10. Gold-Catalyzed Deacylative Cycloisomerization Reactions of 3-Acylindole/ynes: A New Approach for Carbazole Synthesis,Lu Wang, Guijie Li, and Yuanhong Liu*, Org. Lett. 2011, 13, 3786-3789.

11. Grignard Reagent Acceleration of the Intramolecular Diels-Alder Reaction of Furans with Unactivated Alkynes: Toward Structurally Complex Oxabicyclic Alkenes. Yifeng Chen, Lu Wang, Yuanhong Liu* and Yuxue Li*, Chem. Eur. J. 2011, 17, 12582.

12. Regio- and Stereoselective Construction of Highly Functionalized 3-Benzazepine Skeletons through Ring-Opening Cycloamination Reactions Catalyzed by Gold. Xiangwei Du, Shuang, Yang, Jingyu Yang and Yuanhong Liu*, Chem. Eur. J. 2011, 17, 4981-4985.

13. Gold-Catalyzed Approach to Multisubstituted Fulvenes via Cycloisomerization of Furan/Ynes, Yifeng Chen and Yuanhong Liu*, J. Org. Chem. 2011, 76, 5274.

14. Gold-Catalyzed Cascade Friedel-Crafts/Furan-Yne Cyclization/Heteroenyne Metathesis for the Highly Efficient Construction of Phenanthrene Derivatives. Yifeng Chen, Guijie Li and Yuanhong Liu*, Adv. Synth. Catal. 2011, 353, 392– 400.

15. Highly Efficient Synthesis of Multisubstituted 2-Acyl Furans via PIFA/I2 Mediated Oxidative Cycloisomerization of cis-2-En-4-yn-1-ols. Xiangwei Du, Haoyi Chen, Yifeng Chen, Jingjin Chen and Yuanhong Liu*, Synlett 2011, 1010.

16. Gold and Br?nsted Acid Catalyzed Isomerization of [3]Cumulenols and [3]Cumulenones: Efficient Syntheses of 1,5-Dien-3-ynes and Furan Derivatives. Erjuan Wang, Xiaoping Fu, Xin Xie, Jingjin Chen, Hongjun Gao and Yuanhong Liu*, Tetrahedron Lett. 2011, 52, 1968.

17. Highly Stereoselective Synthesis of Trisubstituted cis-[3]Cumulenols from Alkynylated Oxatitanacycles in the Presence of Lewis acids, Chen, J.; Liu,* Y. Organometallics 2010, 29, 505.

18. Gold-Catalyzed Cyclization of Alkynylaziridines as An Efficient Approach Toward Functionalized N-Phth Pyrroles. Xiangwei Du, Xin Xie and Yuanhong Liu*, J Org. Chem. 2010, 75, 510-513.

19. Gold-Catalyzed Benzannulation of 3-Alkoxy-1,5-enynes: Access to Functionalized Benzenes. Guijie Li and Yuanhong Liu*, J. Org. Chem. 2010, 75, 2903–2909.

20. Stereoselective synthesis of enynones via base-catalyzed isomerization of 1,5-disubstituted-2,4-pentadiynyl silyl ethers or their alcohol derivatives.Jingjin Chen, Guoqin Fan and Yuanhong Liu*, Org. Biomol. Chem. 2010, 8, 4806–4810.

21. 过渡金属催化的呋喃合成。卢玉华,宋飞杰,贾学顺*,刘元红*化学进展2010, 22, 58-70.

22. Gold-catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation, Li, G.; Liu,*Y. J. Org. Chem. 2010, 75, 3526.

23. Aldehyde Addition to 1,3-Butadiyne-Derived Zirconacyclocumulenes: Stereoselective Synthesis of cis-[3]Cumulenols, Fu, X.; Liu,* Y.;  Li*, Y. Organometallics 2010, 29, 3012.

24. Diverse Reactivity of Zirconacyclocumulenes Derived from Coupling of Benzynezirconocenes with 1,3-Butadiynes towards Acyl Cyanides: Synthesis of Indeno[2,1-b]pyrroles or [3]Cumulenones. Fu, X.; Chen, J.; Li, G.; Liu,* Y. Angew. Chem. Int. Ed. 2009, 48, 5500.

25. Gold-Catalyzed Cascade Friedel-Crafts/Furan-Alkyne Cycloisomerizations for the Highly Efficient Synthesis of Arylated (Z)-Enones or –Enals. Chen, Y.; Lu, Y.; Li, G.; Liu,* Y. Org. Lett. 2009, 11, 3838.

26. Stereoselective Synthesis of β-Hydroxyallenes with Multiple Contiguous tereogenic Centers via Aldehyde Addition to a-alkenyl-Substituted irconacyclopentenes. Zhou, Y.; Chen, J.; Zhao, C.; Wang, E.; Liu,* Y.; Li,*Y. J. Org. Chem. 2009, 74, 5326.

27. Gold-Catalyzed Intermolecular Reactions of (Z)-Enynols with Indoles for the Construction of Dihydrocyclohepta[b]indole Skeletons through a Cascade Friedel–Crafts/Hydroarylation Sequence. Lu, Y.; Du, X.; Jia, X.; Liu,* Y. Adv. Synth. Catal. 2009, 351, 1517.

28. New Synthetic Approach for the Construction of Multi-Substituted 2-Acyl Furans via IBX-Mediated Cascade Oxidation/Cyclization of cis-2-En-4-yn-1-ols. Du, X.; Chen, H. ; Liu,* Y. Chem. Eur. J. 2008, 14, 9495.

29. Gold-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines and Alkynes Under Solvent-Free Conditions or in Water. Yan, B.; Liu,* Y. Org. Lett. 2007, 9, 4323.

30. General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions. Liu,* Y.; Song, Z.; Yan, B. Org. Lett. 2007, 9, 409.

31. Highly Stereoselective Synthesis of TMS-, Alkyl-, or Aryl Substituted cis-[3]cumulenols via a-alkynylated zirconacyclopentenes. Liu,* Y.; Gao, H.; Zhou, S. Angew. Chem. Int. Ed. 2006, 45, 4163.