Hou, Xuelong   Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone: +86 21 54925144

Fax: +86 21 54925100

Email: xlhou@sioc.ac.cn

Education:

1975 - 1978  Faculty of Pharmacy, Shanghai First Medical College, China

1980 - 1986  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Ph D graduate student (Supervisors: Professors Henry N. C. Wong & Wei Yuan Huang)

Academic Career:

1978 - 1980  Department of Medicinal Chemistry, Faculty of Pharmacy, Shanghai First Medical College, Assistant

1986 - 1987  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Research Associate

1987 - 1989  Institute of Organic Chemistry, University of Cologne, Germany, Postdoct (with Professor E. Vogel)

1989 - 1992  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Research Associate

1992 - 1997  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Associate Professor

09/1997 - present   Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Professor

07/2006 - 08/2006  Visiting Professor, Osaka University, Japan

02/2010 - 03/2010 Visiting Professor, Université Paul Sabatier, Toulouse, France 

Awards & Honors:

Alexander von Humboldt Foundation Research Fellow, Germany (1987-1989)

Second Class Prize of National Natural Science of China (1997)

National Outstanding Youth Fund (2000-2003)

First Class Award of Science and Technology Advancement, Shanghai (2001)

Second Class Prize of National Natural Science of China (2002)

JSPS Fellow, Japan (2002)

Eli Lilly Scientific Excellence Award in China (2005)

Leadership of Shanghai (2007)

Peking University-Eli Lilly Lectureship (2009)

Research Interests:

OMCOS, design, synthesis and applications of chiral ligands in asymmetric catalysis, asymmetric catalysis via organometallics, transformation of organic compounds under non-metal conditions

Selective Publications:

1. Yan, X. X.; Liang, C. G.; Zhang, Y.; Hong, W.; Cao, B. X.; Dai, L. X.; Hou, X. L.* Highly Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketones Angew. Chem. Int. Ed.  2005, 44, 6544-6546

2. Xiao-Xia Yan, Qian Peng, Yan Zhang, Kai Zhang, Wei Hong, Xue-Long Hou* and Yun-Dong Wu A Highly Enantio- and Diastereoselective Cu-Catalytic 1,3-Dipolar Cycloaddition of Azomethine Ylides with Nitroalkenes Angew. Chem. Int. Ed. 2006, 45, 1979-1983.

3. Zheng, W.-H.; Zheng, B.-H.; Zhang, Y.; Hou, X.-L.* Highly Regio-, Diastereo- and Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketone Enolates with Monosubstituted Allyl Substrates  J. Am. Chem. Soc. 2007, 129, 7718-7719

4. Zhang, K.; Peng, Q.; Hou, X.-L.*; Wu, Y.-D. Highly Enantioselective Palladium-Catalyzed alkylation of Acyclic Amides Angew. Chem. Int. Ed. 2008, 47, 1741

5. Wen-Qiong Wu, Qian Peng, Da-Xuan Dong, Xue-Long Hou* and Yun-Dong Wu* A Dramatic Switch of Enantioselectivity in Asymmetric Heck Reaction by Benzylic Substituents of Ligands J. Am. Chem. Soc. 2008, 129, 9717-9725

6. Xiao Xia Yan, Qian Peng, Qing Li, Kai Zhang, Jun Yao, Xue Long Hou*, Yun Dong Wu* Highly Diastereoselectivity Switchable Enantioselective Mannich Reaction of Glycine Derivatives with Imines J. Am. Chem. Soc. 2008, 130, 14362-14363

7.  Wei Jing Lu, Yun Wei Chen, Xue Long Hou* Iridium-Catalyzed Highly Enantioselective Hydrogenation of the C=C bond of α, β-Unsaturated Ketones Angew. Chem. Int. Ed. 2008, 47, 10133-10136

8. Wei Liu, Di Chen, Xia-Zhen Zhu, Xiao-Long Wan and Xue-Long Hou* Highly Diastereo- and Enantioselective Pd-Catalyzed Cyclopropanation of Acyclic Amides with Substituted Allyl Carbonates J. Am. Chem. Soc. 2009, 131, 8734-8735

9. Lei, B.-L.; Ding, C.-H.; Yang, X.-F.; Wan, X.-L.; and Hou, X.-L.* Highly Efficient Kinetic Resolution of 2-Substituted-2,3-Dihydro-4-Quinolones by  Palladium-Catalyzed Asymmetric Allylic Alkylation J. Am. Chem. Soc. 2009, 131, 18250-18251

10. Hai-Lin Liu, Di Chen, Xue-Long Hou*, Michal Sabat, and Lin Pu* Highly Enantioselective Recognition of Structurally Diverse a-Hydroxycarboxylic Acids by a Fluorescent Sensor Angew. Chem. Int. Ed. 2010, 49, 602-606