Shi, Shiliang----State Key Laboratory of Organometallic Chemistry 345 Lingling Lu, Shanghai

Shi, Shiliang Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, Shanghai 200032

Phone/Fax: +86 21 54925580

Email:shiliangshi@sioc.ac.cn

EducationandResearch Experience:

2016.06-Present:Professor, State Key Laboratory of Organometallic Chemistry, SIOC

2012.11-2016.05:Postdoctoral Associate,Department of Chemistry,Massachusetts Institute of Technology(Advisor: Prof.Stephen L. Buchwald)

2011.10-2012.10 JSPSPostdoctoralFellow,Graduate School of Pharmaceutical Sciences, University of Tokyo,(Advisor: Prof.Motomu Kanai)

2008.10-2011.09Ph.D.,Graduate School of Pharmaceutical Sciences,University of Tokyo,(Advisor: Prof.Masakatsu Shibasaki and Motomu Kanai)

Awards & Honors:

Thieme Chemistry Journals Award (2019)

Bayer Investigator Award (2021)

Shanghai Academic Research Leader (Youth, 2022)

Research Interest:

· Development of New Privileged Chiral Ligands

· Development of Novel, Efficient, and Practical Enantioselective Catalytic Reactions

· Design and Syntheses of New Optically Active Polymers

Selected Publications：

1.Lin-Xin Ruan, Bo Sun, Jia-Ming Liu,Shi-Liang Shi*Dynamic kinetic asymmetric arylation andalkenylationof ketones.Science2023,379, 662-670. 　

2. Chen-Fei Liu#, Zi-Chao Wang#, Xiaohua Luo#, Jiawei Lu, Charyl Hui Min Ko,Shi-Liang Shi*, Ming Joo Koh* Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings.Nat. Catal.2022,5, 934-942.

3. Jun-Bao Ma, Xia Zhao, Dongju Zhang*,Shi-Liang Shi*Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation.J. Am. Chem. Soc.2022,144, 13643-13651.

4. Wu-Bin Zhang, Guang Chen,Shi-Liang Shi* Enantioselective Ni/N-Heterocyclic Carbene-Catalyzed Redox-Economical Coupling of Aldehydes, Alkynes, and Enones for Rapid Construction of Acyclic All-Carbon Quaternary Stereocenters.J. Am. Chem. Soc.2022,144, 130-136.

5. Zi-Chao Wang, Jian Gao, Yuan Cai, Xiaodong Ye,Shi-Liang Shi*Chemo- and Enantioselective Arylation and Alkenylation ofAldehydes Enabled by Nickel/ N-Heterocyclic Carbene Catalysis.CCS Chem.2022,4, 1169-1179.

6. Binyang Jiang,Shi-Liang Shi*Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides.Chin. J. Chem.2022,40, 1813-1820.

7. Lei Gao, Sheng Liu, Zi-Chao Wang, Yongjun Mao*,Shi-Liang Shi*Ligand- and Additive-Free CuCl₂-Catalyzed para-C-H Alkylation ofAniline Derivatives via Carbene Insertion.Asian J. Org. Chem.2022, 11, e202100723.

8. Yurong Zhang, Han Wang*, Yongjun Mao,Shi-Liang Shi*Ni-Catalyzed Three-Component Coupling Reaction of Butadi-ene, Aldimines and Alkenylboronic Acids.Chin. J. Org. Chem.2022, 42, 1198-1209.

9. Binyang Jiang,Shi-Liang Shi*Recent Progress in Upgrading of Alcohol and Amine viaAsymmetric Dehydrogenative Coupling.Chin. J. Org. Chem.2022,42, 3263-3279.

10. Yuan Cai,Shi-Liang Shi*Enantioconvergent Arylation of Racemic Secondary Alcohols to Chiral Tertiary Alcohols Enabled by Nickel/N-Heterocyclic Carbene Catalysis.J. Am. Chem. Soc.2021,143, 11963-11968.

11. Zi-Chao Wang, Pei-Pei Xie, Youjun Xu, Xin Hong*,Shi-Liang Shi*Low-Temperature Ni-Catalyzed C-N Cross-Coupling via Kinetic Resolution Enabled by a Bulky yet Flexible Chiral N-Heterocyclic Carbene Ligand.Angew. Chem. Int. Ed.2021,60, 16077-16084.

12. Yuan Cai, Lin-Xin Ruan, Abdul Rahman,Shi-Liang Shi*Fast Enantio- and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/NHC Catalysis.Angew. Chem., Int. Ed.2021,60, 5262-5267.

13. Yu-Qing Li, Guang Chen,Shi-Liang Shi*Regio- and Trans-Selective Ni-Catalyzed Coupling of Butadiene,Carbonyls, and Arylboronic Acids to Homoallylic Alcohols underBase-Free Conditions.Org. Lett.2021,23, 2571-2577.

14. Yu-Qing Li,Shi-Liang Shi*Ni-Catalyzed Coupling of Butadiene, Aldimines, and ArylboronicAcids to Homoallylic Amines under Base-Free Conditions.Organometallics2021, 40, 2345-2353.

15. Yuan Cai,Shi-Liang Shi*ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of a-Olefins.Synlett2021,32, 545-550.

16. Shichao Wei, Yongjun Mao*,Shi-Liang Shi*Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane.Synlett2021,32, 1670-1674.

17. Yu-Qing Li,Shi-Liang Shi*Nickel Catalyzed Multicomponent Coupling of Butadiene, Aldehydes, Alkynes, and Schwartz Reagent to Form 1,4 dienes.Chin. J. Org. Chem.2021,41, 1939-1948.

18. Di Shen, Wu-Bin Zhang, Zhiyang Li,Shi-Liang Shi*, Youjun Xu*Nickel/NHC-Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes.Adv. Synth. Catal.2020,362, 1125-1130.

19. Yu-Qing Li, Feng Li,Shi-Liang Shi*Expedient Synthesis of Ketones via N-Heterocyclic Carbene/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes.Chin. J. Chem.2020,38, 1035-1039.

20. Zi-Chao Wang, Youjun Xu,Shi-Liang Shi*Base-Promoted Rapid Hydrosilylation of Aldimine.Chin. J. Org. Chem.,2020,40, 3463-3466.

21. Wu-Bin Zhang, Xin-Tuo Yang, Jun-Bao Ma, Zhi-Min Su,Shi-Liang Shi*Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis.J. Am. Chem. Soc.2019,141, 5628-5634.

22. Di Shen, Youjun Xu,Shi-Liang Shi*A Bulky Chiral N-Heterocyclic Carbene Palladium Catalyst Enables Highly Enantioselective Suzuki-Miyaura Cross-Coupling Reactions for the Synthesis of Biaryl Atropisomers.J. Am. Chem. Soc.2019,141, 14938-14945.

23. Yuan Cai, Xiaodong Ye, Sheng Liu,Shi-Liang Shi*Nickel/NHC-Catalyzed Asymmetric C–H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins.Angew. Chem. Int. Ed.2019,58, 13433-13437.

24. Yuan Cai, Jia-Wen Zhang, Feng Li, Jia-Ming Liu,Shi-Liang Shi*Nickel/N-Heterocyclic Carbene Complex-Catalyzed Enantioselective Redox-Neutral Coupling of Benzyl Alcohols and Alkynes to Allylic Alcohols.ACS Catal.2019,9, 1-6.

25. Zi-Chao Wang, Di Shen, Jian Gao, Xian Jia, Youjun Xu*,Shi-Liang Shi*Base-Catalysed Reductive Relay Hydroboration of Allylic Alcohols with Pinacolborane to Form Alkylboronic Esters.Chem. Common.,2019,55, 8848. (Invited Contribution to theChemCommEmerging Investigators Issue 2019).

26. Zi-Chao Wang, Min Wang, Jian Gao,Shi-Liang Shi,*Youjun Xu*ⁿBuLi-Promotedanti-Markovnikov Selective Hydroboration of Unactivated Alkenes and Internal Alkynes.Org. Chem. Front.2019,6, 2949-2953.

27. Feng Li, Xu Bai, Yuan Cai, Han Li, Shuo-Qing Zhang, Feng-Hua Liu, Xin Hong*, Youjun Xu*Shi-Liang Shi*Aluminum-Catalyzed Selective Hydroboration of Alkenes and Alkynylsilanes.Org. Process Res. Dev.,2019,23, 1703-1708.

28. Yuan Cai, Xin-Tuo Yang, Shuo-Qin Zhang, Feng Li, Yu-Qin Li, Lin-Xin Ruan, Xin Hong*,Shi-Liang Shi*Copper-Catalyzed Enantioselective Markovnikov Protoboration ofa-Olefins Enabled by a Buttressed N-Heterocyclic Carbene Ligand.Angew. Chem. Int. Ed.2018,57, 1376-1380.

29. Yuan Cai, Feng Li, Yu-Qing Li, Wu-Bin Zhang, Feng-Hua Liu*,Shi-Liang Shi*Base metal-catalyzed alcohol C–C couplings under hydrogen transferconditions.Tetrahedron Lett.2018,59, 1073-1079.

30.Shi-Liang Shi,Zackary L. Wong,Stephen L. Buchwald* Copper-Catalyzed Enantioselective Stereodivergent Synthesis of Amino Alcohols.Nature2016,532,353.

31.Shi-Liang Shi,Stephen L. Buchwald* Copper-catalysed Selective Hydroamination Reactions of Alkynes.Nature Chemistry2015,7, 38. (Highlighted inNature.Nature517, 280.)

32. Yang Yang#,Shi-Liang Shi#, Dawen Niu, Peng Liu, Stephen L. Buchwald* Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines.Science2015,349, 62. (#: Co-first author) (Highlighted inChemistry WorldandC&EN)