Chen, Pinhong  Associate Professor

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry

Chinese Academy of Sciences

345 Lingling Lu, Shanghai 200032

Phone: +86 21 54925482

E-mail:pinhongchen@sioc.ac.cn

Education: 

2004.09 - 2010.03　 Ph.D. 　CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CASSupervisor: Prof. Chaozhong Li

2000.09 - 2004.07　 B.S. 　Department of Chemistry, Jilin University

Research Experience:

2012.02 - Present: Associate Professor, State Key Laboratory of OrganometallicChemistry, Shanghai Institute of Organic Chemistry, CAS (Prof. Guosheng Liu)

2010.07 - 2011.12  　　Postdoctoral Associate, Department of Pharmacology, Baylor College of Medicine, USA (Prof. Yongcheng Song)

2011.03 - 2011.06　Research Associate: CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CAS (Prof. Chaozhong Li)

Research Interest:

Transition metal catalyzed fluorination and their applications in synthesis of fluorinated active compounds and natural products.

Selected Publications:1.Yuan Yao,Pinhong Chen, Jiasheng Diao, Gang Cheng, Lisheng Deng, Justin L. Anglin, B. V. Venkataram Prasad, and Yongcheng Song* Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.J. Am. Chem. Soc.,2011,133, 16746–16749;

2.Lisheng Deng, Jiasheng Diao,Pinhong Chen, Venugopal Pujari, Yuan Yao, Gang Cheng,Dean C. Crick, B. V. Venkataram Prasad, and Yongcheng Song* Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies.J. Med. Chem.,2011,54, 4721–4734;

3.Pinhong Chen, Lidong Cao, Wenhai Tian, Xinfeng Wang, and Chaozhong Li* Total synthesis and absolute configuration determination of (+)-subincanadine F.Chem. Commun.,2010,46, 8436-8438;

4.Pinhong Chen, Lidong Cao, and Chaozhong Li* Protecting-Group-Free Total Synthesis of (±)-Subincanadine F.J. Org. Chem.2009,74, 7533-7535;

5.Pinhong Chen, Junhua Wang,* Kun Liu, and Chaozhong Li* Synthesis and Structural Revision of (±)-Laurentristich-4-ol.J. Org. Chem.2008,73, 339-341.